SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID: CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON
SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID: CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON
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DOI：
10.3987/com-08-s(d)42
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发表时间：
2009-04-01
期刊：
影响因子：
0.6
通讯作者：
Fukuyama, Tohru
中科院分区：
文献类型：
--
作者：
Inoue, Tohru;Yokoshima, Satoshi;Fukuyama, Tohru
我们已经成功地构建了麦角酸的四环骨架，其特征在于在吲哚的C3位置的酰化以及分子内Heck反应。光学活性的D环单元可以由L-焦谷氨酸通过二溴环丙烷的对旋电环化反应得到。
We have successfully constructed the tetracyclic skeleton of lysergic acid, which features an acylation at the C3 position of the indole as well as an intramolecular Heck reaction. The optically active D ring unit could be derived from L-pyroglutamic acid via a disrotatory electrocyclic reaction of a dibromocyclopropane.