Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes
Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes
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DOI：
10.1038/s41430-022-01170-x
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发表时间：
2022-06-10
影响因子：
4.7
通讯作者：
Ohga, Shouichi
中科院分区：
文献类型：
--
作者：
Chong, Pin Fee;Torio, Michiko;Ohga, Shouichi
维生素缺乏是自闭症谱系障碍（ASD）儿童管理中的一个新问题。需要特别注意识别由不平衡的食物摄入引起的可变体征。我们在此报告两例患有多种维生素缺乏症的病人，他们需要重症监护，表现出不同的症状。患者1与'Shoshin'脚气病表现为心脏骤停，硫胺素缺乏发展严重的神经系统后遗症，尽管快速补充维生素。患者2，谁有腿部疼痛和跛行步态，表现出快速恢复静脉输液和管喂养后，被诊断为坏血病。一项文献检索发现了几名患有严重硫胺素缺乏症的ASD儿童，但很少有报告记录了发作时心脏骤停形式的危及生命的情况。考虑到ASD儿童食物选择性的高观察率，需要早期干预，以防止维生素缺乏加重为严重的神经功能障碍。
Vitamin deficiencies are an emerging concern in the management of children with autism spectrum disorder (ASD). Particular attention is required for recognizing the variable signs caused by unbalanced food intakes. We herein report two patients with multiple vitamin deficiencies who needed critical care showing different prognoses. Patient 1 with 'Shoshin' beriberi presenting with cardiac arrest had thiamine deficiency developed severe neurological sequelae despite rapid vitamin supplementation. Patient 2, who had leg pain and a limping gait, showed a rapid recovery with intravenous infusion and tube feeding after being diagnosed with scurvy. A literature search revealed several children with ASD with critically ill thiamine deficiency, but few reports documented a life-threatening condition in the form of cardiac arrest at the onset. Considering the high observation rate of food selectivity in children with ASD, early intervention is required to prevent the exacerbation of vitamin deficiencies to severe neurological disabilities.