CENTRAL MONOAMINES AND ANTINOCICEPTIVE DRUG ACTION
CENTRAL MONOAMINES AND ANTINOCICEPTIVE DRUG ACTION
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DOI：
10.1016/0014-2999(72)90146-x
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发表时间：
1972-01-01
影响因子：
5
通讯作者：
FREY, HH
中科院分区：
文献类型：
--
作者：
GORLITZ, BD;FREY, HH
本实验旨在阐明中枢5-HT和儿茶酚胺在d-苯丙胺、d-对-氯苯丙胺、吗啡和氨基比林的抗伤害效应中的作用。用Randall和Selitto（1957）的方法测定抗伤害性效应，用对氯苯丙氨酸预处理可拮抗安非他明和吗啡的抗伤害性效应，用5-HTP恢复。5-HT拮抗剂赛庚啶也有较强的拮抗作用。吗啡和对氯苯丙胺的抗伤害作用时，5-HT的中枢转换增强。α-甲基酪氨酸在很低剂量下就能消除抗伤害性药物的作用，而双硫仑则不能。在儿茶酚胺拮抗药物中，氟哌啶醇在必须被认为是纯粹多巴胺拮抗剂的剂量下被证明是有效的。因此，结果表明5-HT和多巴胺参与了抗伤害性药物作用的中枢介导。在这些胺中，前者似乎对吗啡和对氯苯丙胺具有重要意义，后者对苯丙胺具有重要意义。在氨基比林的情况下，只有预处理与p-氯苯丙氨酸导致有点可疑的拮抗作用。
Experiments were perfomed in rats to elucidate the role of central 5-HT and catecholamines in the mediation of the antinociceptive effects of d-amphetamine, d-p-chloroamphetamine, morphine and aminopyrine. The method of Randall and Selitto (1957) was used for determining the antinociceptive effect.The antinociceptive effects of both amphetamines and of morphine was antagonized by pretreatment with p-chlorophenylalanine and restored by 5-HTP. The 5-HT antagonist, cyproheptadine also exerted a strong antagonism. Central turnover of 5-HT was enhanced at the time of the antinociceptive effects of morphine and p-chloroamphetamine. α-Methyltyrosine abolished the antinociceptive drug effects in very low doses, but disulfiram did not. Of the catecholamine antagonistic drugs, haloperidol proved to be effective in doses which must be considered as purely dopamine antagonistic. Therefore, the results point to a participation of 5-HT and dopamine in the central mediation of antinociceptive drug effects. Of these amines, the former seems to be a major significance for morphine and p-chloroamphetamine, the latter for amphetamine. In the case of aminopyrine, only pretreatment with p-chlorophenylalanine resulted in a somewhat doubtful antagonism.