SYSTEMIC NEUROAXONAL DYSTROPHY IN SUFFOLK SHEEP
SYSTEMIC NEUROAXONAL DYSTROPHY IN SUFFOLK SHEEP
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DOI：
10.1007/bf00687690
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发表时间：
1967-01-01
影响因子：
12.7
通讯作者：
BRADFORD, GE
中科院分区：
文献类型：
--
作者：
CORDY, DR;RICHARDS, WP;BRADFORD, GE
萨福克绵羊出现进行性共济失调，出现在1 1/2 - 5个月时。的年龄后，一段时间的临床正常，报告。这种情况被认为是遗传性的，可能是隐性的，尽管还不能确定只涉及一个单一的基因座。病变的特点是来自轴突的远端部分的球体。尸体似乎经历了水肿和最终溶解。在短期临床观察期间，未观察到神经元坏死或束变性。球状体分布在一个独特的系统模式，涉及视觉和本体感受的途径。与其他神经轴索营养不良的比较。
A progressive ataxia in Suffolk sheep, appearing at 1 1/2 -5 mo. of age after a period of clinical normality, is reported. The condition is regarded as hereditary and probably recessive, although it is not established that only a single locus is involved. Lesions were characterized by spheroids derived from the distal portions of axons. The bodies appeared to undergo hydropic swelling and eventual lysis. During the short periods of clinical observation, neither neuron necrosis nor tract degeneration were observed. The spheroids were distributed in a unique systemic pattern involving visual and proprioceptive pathways. Comparisons are made with other neuroaxonal dystrophies.