Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice
Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice
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DOI：
10.1007/s10787-007-1549-5
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发表时间：
2007-06-01
影响因子：
5.8
通讯作者：
Tsuchimoto, K.
中科院分区：
文献类型：
--
作者：
Nakamura, M.;Matsui, H.;Tsuchimoto, K.
海尔曼氏幽门螺杆菌(HH)与胃低度恶性MALT淋巴瘤有一定关系。最近，我们在C57BL/6小鼠体内形成了胃MALT淋巴瘤。材料和方法：C5713L/6小鼠感染食蟹猴HH 6个月以上。结果：感染小鼠几乎100%形成MALT淋巴瘤。结论：HH与MALT淋巴瘤的形成有关，提示VEGF在MALT淋巴瘤的发生中起一定作用。
Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.Materials and methods: C5713L/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performedResults: MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.Conclusion: Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.