A NEW DIHYDROOXAZOLE ANTIBIOTIC FROM THE FERMENTATION BROTH OF STREPTOMYCES DJAKARTENSIS
A NEW DIHYDROOXAZOLE ANTIBIOTIC FROM THE FERMENTATION BROTH OF STREPTOMYCES DJAKARTENSIS
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一种新型二氢恶唑抗生素 一种新型二氢恶唑抗生素
DOI：
10.3987/com-14-13001
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发表时间：
2014-07-01
期刊：
影响因子：
0.6
通讯作者：
Wu, Wen-Jun
中科院分区：
文献类型：
--
作者：
Zhang, Ji-Wen;Zhang, Wen-Juan;Wu, Wen-Jun
通过生物测定引导的分级分离，从雅卡链霉菌的发酵液中分离出一种新的抗生素。主要通过2D NMR和MS谱数据分析，将其鉴定为(S)-2-(2-羟苯基)-4-羟甲基-4,5-二氢恶唑，并通过X射线晶体数据确定该抗生素的绝对构型，并证明是已知抗生素Nocazoline A或spoxazomicin C的对映体。具有广谱抗菌活性，MIC值为7.81，与31.25μ相似。克/毫升。
A new antibiotic was isolated from the fermentation broth of Streptomyces djakartensis by bioassay-guided fractionation. It was elucidated as (S)-2-(2-hydroxyphenyl)-4-hydroxymethyl-4,5-dihydrooxazole mainly by analyses of 2D NMR and MS spectral data and the absolute configuration of the antibiotic was established by X-ray crystal data and proved to be an enantiomer of known antibiotic with name of Nocazoline A or spoxazomicin C. It exhibited broad spectrum antibacterial activities with MIC values of 7.81 similar to 31.25 mu g/mL.