Comparison of Anticholinergic Risk Scales and Associations with Adverse Health Outcomes in Older People
Comparison of Anticholinergic Risk Scales and Associations with Adverse Health Outcomes in Older People
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DOI：
10.1111/jgs.13206
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发表时间：
2015-01-01
影响因子：
6.3
通讯作者：
Nishtala, Prasad S.
中科院分区：
文献类型：
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作者：
Salahudeen, Mohammed Saji;Hilmer, Sarah N.;Nishtala, Prasad S.
目的调查已发表的9个抗胆碱能量表的抗胆碱能负荷得分是否与不良健康结局有关，包括住院、因跌倒住院、住院时间(LOS)和更多去全科医生(GP)就诊。设计药物流行病学人群研究。背景新西兰。参与者65岁及以上人口(n=537,387)。测量方法分析了来自制药声明数据市场数据集(2011)的537,387人的数据。使用9个已发表的量表计算抗胆碱能药物暴露。事件信息(2012年)是根据《国际疾病分类，第十次修订，代码》从国家最低数据集中提取的。通过对年龄、性别、种族、合并症和多种药物进行调整的回归模型，对住院、因跌倒住院、因跌倒住院和因全科医生就诊的预测因素进行检验。结果根据不同的等级，接触抗胆碱能药物的比例从22.8%到55.9%不等。多元回归分析显示，根据所有9个量表量化的抗胆碱能负荷评分与入院、因跌倒住院、因跌倒而住院、因全科医生就诊显著相关(P
ObjectivesTo investigate whether anticholinergic burden scores from nine published anticholinergic scales are associated with adverse health outcomes, including hospital admissions, hospitalizations for falls, hospital length of stay (LOS), and more visits to general practitioners (GPs).DesignPharmacoepidemiological population-based study.SettingNew Zealand.ParticipantsPopulation aged 65 and older (n=537,387).MeasurementsData were analyzed for 537,387 individuals from the Pharmaceutical Claims Data Mart data set (2011). Anticholinergic medication exposure was calculated using nine published scales. Events information (2012) was extracted from the National Minimum Datasets using International Classification of Diseases, Tenth Revision, codes. Predictors of hospital admissions, hospitalizations for falls, LOS, and GP visits were examined using regression models adjusting for age, sex, ethnicity, comorbidities, and polypharmacy.ResultsPrevalence of exposure to anticholinergic medicines ranged from 22.8% to 55.9% according to the different scales. Multivariate regression analysis showed that anticholinergic burden scores quantified according to all nine scales were significantly associated with hospital admissions, hospitalizations for falls, LOS, and GP visits (P