Functional Connectivity of the Striatum in Schizophrenia and Psychotic Bipolar Disorder
Functional Connectivity of the Striatum in Schizophrenia and Psychotic Bipolar Disorder
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DOI：
10.1016/j.bpsc.2019.05.017
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发表时间：
2019-11-01
影响因子：
5.9
通讯作者：
Woodward, Neil D.
中科院分区：
文献类型：
--
作者：
Karcher, Nicole R.;Rogers, Baxter P.;Woodward, Neil D.
背景：精神分裂症患者的纹状体异常，可能代表了精神障碍的一种常见神经生物学机制。静息状态功能磁共振成像研究尚未就精神分裂症的纹状体连接障碍达成共识，尽管这些研究通常发现额顶和突起网络连接受损。本研究的目的是阐明皮质纹状体连接的模式，包括皮质纹状体连接障碍是否是跨诊断的并延伸到精神病双相情感障碍。方法：我们检测了60名健康受试者和117名精神病患者的皮质纹状体功能连接，包括77例精神分裂症谱系疾病和40例精神病双相情感障碍。我们进行了基于皮质种子的感兴趣区分析，并对任何有意义的结果进行了后续体素分析。结果：皮质感兴趣区分析表明，精神病患者纹状体与纹状体的整体连接性降低，后续体素分析定位于左侧壳核。基于纹状体种子的分析显示，在精神分裂症和精神病双相情感障碍患者中，腹侧嘴侧壳核与内侧前额叶皮质突起网络部分的连接减少。结论：本研究发现精神分裂症和精神病双相情感障碍患者存在跨诊断皮质纹状体连接障碍的证据，包括突起网络连接减少，以及壳核和内侧前额叶皮质之间的连接减少。总体而言，目前的研究指出了显著网络连接不足在精神障碍中的相对重要性。
BACKGROUND: The striatum is abnormal in schizophrenia and possibly represents a common neurobiological mechanism underlying psychotic disorders. Resting-state functional magnetic resonance imaging studies have not reached a consensus regarding striatal dysconnectivity in schizophrenia, although these studies generally find impaired frontoparietal and salience network connectivity. The goal of the current study was to clarify the pattern of corticostriatal connectivity, including whether corticostriatal dysconnectivity is transdiagnostic and extends into psychotic bipolar disorder.METHODS: We examined corticostriatal functional connectivity in 60 healthy subjects and 117 individuals with psychosis, including 77 with a schizophrenia spectrum illness and 40 with psychotic bipolar disorder. We conducted a cortical seed-based region-of-interest analysis with follow-up voxelwise analysis for any significant results. Further, a striatum seed-based analysis was conducted to examine group differences in connectivity between the striatum and the whole cortex.RESULTS: Cortical region-of-interest analysis indicated that overall connectivity of the salience network with the striatum was reduced in psychotic disorders, which follow-up voxelwise analysis localized to the left putamen. Striatum seed-based analyses showed reduced ventral rostral putamen connectivity with the salience network portion of the medial prefrontal cortex in both schizophrenia and psychotic bipolar disorder.CONCLUSIONS: The current study found evidence of transdiagnostic corticostriatal dysconnectivity in both schizophrenia and psychotic bipolar disorder, including reduced salience network connectivity, as well as reduced connectivity between the putamen and the medial prefrontal cortex. Overall, the current study points to the relative importance of salience network hypoconnectivity in psychotic disorders.