Bone material properties in trabecular bone from human iliac crest biopsies after 3-and 5-year treatment with risedronate
Bone material properties in trabecular bone from human iliac crest biopsies after 3-and 5-year treatment with risedronate
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DOI：
10.1359/jbmr.060701
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发表时间：
2006-10-01
影响因子：
6.2
通讯作者：
Klaushofer, Klaus
中科院分区：
文献类型：
--
作者：
Durchschlag, Erich;Paschalis, Eleftherios P.;Klaushofer, Klaus
利塞膦酸钠对骨质疏松妇女三髂嵴活检中骨矿物质成熟度/结晶度和胶原交联率的长期影响进行了评价。在这项双盲研究中，利塞膦酸钠治疗3年和5年，阻止了未经治疗的骨质疏松症和其他抗吸收药治疗的骨质疏松症的组织老化。这种作用可能有助于利塞膦酸钠的抗骨折疗效。
Long-term effects of risedronate on bone mineral maturity/crystallinity and collagen cross-link ratio in triple iliac crest biopsies of osteoporotic women were evaluated. In this double-blinded study, 3- and 5-year treatment with risedronate arrested the tissue aging encountered in untreated osteoporosis and in osteoporosis treated with other antiresorptives. This effect may be contributing to risedronate's antifracture efficacy.