Hepcidin expression and iron parameters change in Type 2 diabetic patients
Hepcidin expression and iron parameters change in Type 2 diabetic patients
复制标题
2型糖尿病患者Hepcidin表达及铁参数变化
DOI：
10.1016/j.diabres.2011.03.028
复制
发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Jiao, Xiao-Yang
中科院分区：
文献类型：
--
作者：
Jiang, Fang;Sun, Zhen-Zhen;Jiao, Xiao-Yang
目的：铁可能参与2型糖尿病（DM）的发病。本研究的目的是确定铁调节剂hepcidin和铁代谢参数在2型DM患者，它们之间的关系进行了评估，在这个特定的subgroups.Materials和方法：本研究包括64人：34例糖尿病患者和30名年龄匹配的对照。结果：糖尿病患者血清铁蛋白、铁调素水平均显著高于对照组（P < 0.001），血清白细胞介素6（IL-6）、超敏C反应蛋白（hsCRP）、铁蛋白（ferritin）、可溶性转铁蛋白受体（sTfR）、促红细胞生成素（EPO）水平均显著高于对照组（P < 0.001）。糖尿病组和正常对照组铁调素与铁蛋白、铁蛋白与IL-6水平呈正相关（p < 0.001）。所有这些数据表明，糖尿病患者中较高的铁调素水平可能是由于那些较高的铁蛋白和IL-6水平，hepcidin升高可能通过下调铁吸收而具有适应性价值，在2型糖尿病的发病中起重要作用。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Aim: Iron may contribute to the pathogenesis of Type 2 diabetes mellitus (DM). The aim of this study was to determine iron regulator hepcidin and iron metabolic parameters in Type 2 DM patients, the relationships among them were evaluated in this specific sub-groups.Materials and methods: The study included sixty-four people: 34 cases of diabetes and 30 age-matched controls. Serum hepcidin, IL-6, hsCRP, ferritin, sTfR, EPO as well as other clinical parameters were detected, and the associations between hepcidin levels and iron/inflammatory parameters were analyzed in diabetes and the controls.Results: Serum ferritin and hepcidin levels in diabetic patients were significant higher than the controls (p < 0.001 respectively). A positive correlation between hepcidin and ferritin, as well as between ferritin and IL-6 levels was existed in diabetes and the control groups (p < 0.001 respectively).Conclusion: All of these data demonstrated that the higher hepcidin levels in diabetic patients may be due to those higher ferritin and IL-6 levels, the elevated hepcidin might have adaptive value through down-regulated iron absorb and play an important role in pathogenesis of Type 2 DM. (C) 2011 Elsevier Ireland Ltd. All rights reserved.