SUBSTANCE-P-LIKE IMMUNOREACTIVITY IN NERVES ASSOCIATED WITH THE VASCULAR SYSTEM OF GUINEA-PIGS
SUBSTANCE-P-LIKE IMMUNOREACTIVITY IN NERVES ASSOCIATED WITH THE VASCULAR SYSTEM OF GUINEA-PIGS
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DOI：
10.1016/0306-4522(82)90279-2
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
ESKAY, RL
中科院分区：
文献类型：
--
作者：
FURNESS, JB;PAPKA, RE;ESKAY, RL
用间接免疫组织化学技术，在豚鼠血管的全标本和切片中，定位了P物质样免疫反应。有一个广泛的协会的神经纤维，P物质样免疫反应与血管，延伸到所有的血管床。不同血管的相对供应密度进行了目视评估，并使用评级量表进行比较。靠近心脏的大弹性动脉有密集的免疫反应神经网络与它们相关。密度随着接近周围床而降低，除了内脏床的动脉有特别密集的神经网络。心肌、中枢神经系统、肾、生殖和骨骼肌床的动脉均有不同程度的P物质免疫反应阳性神经与之相连。心脏附近的腔静脉供应密集，但很少有纤维及其更外围的延伸。一些大静脉（例如，肺、肝门和上级肠系膜）有少量纤维，而周围血管床的静脉则很少或没有免疫反应性神经纤维。物质P-样免疫反应性血管神经显着减少，在豚鼠注射辣椒素，但不受6-羟基多巴胺的注射。血管P物质免疫反应神经可能是感觉起源。
Substance P-like immunoreactivity was localized by an indirect immunohistochemical technique in whole mounts and sections of blood vessels from the guinea pig. There was a widespread association of nerve fibers that had substance P-like immunoreactivity with blood vessels, extending into all vascular beds. The relative densities of supply of different vessels were assessed visually and a rating scale used to compare them. Large elastic arteries close to the heart had dense networks of immunoreactive nerves associated with them. The density decreased as more peripheral beds were approached, except that there was a particularly dense network of nerves with arteries of the splanchnic beds. Arteries to myocardial, CNS, renal, reproductive and skeletal muscle beds all had substance P-immunoreactive nerves associated with them to varying extents. The venae cavae near the heart were densely supplied, but there were few fibers with their more peripheral extensions. Some large veins (e.g., pulmonary, hepatic portal and superior mesenteric) had a few fibers with them, but veins of peripheral vascular beds had very few or no immunoreactive nerve fibers. Substance P-like immunoreactivity in vascular nerves was markedly reduced in guinea pigs that were injected with capsaicin but was unaffected by the injection of 6-hydroxydopamine. Vascular substance P-immunoreactive nerves are likely to be of sensory origin.