Optical coherence tomography findings in adult-onset foveomacular vitelliform dystrophy
Optical coherence tomography findings in adult-onset foveomacular vitelliform dystrophy
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DOI：
10.1016/s0002-9394(02)01685-9
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发表时间：
2002-11-01
影响因子：
4.2
通讯作者：
Brancato, R
中科院分区：
文献类型：
--
作者：
Pierro, L;Tremolada, G;Brancato, R
摘要：本文的目的是分析成人黄斑黄斑病变(AOFVD)患者视网膜下黄斑病变的光学相干断层扫描(OCT)图像，比较病变上方神经视网膜厚度与最佳矫正视力(BCVA)的差异，并将AOFVD患者的OCT图像与Best疾病的OCT进行比较。设计：观察性病例系列。对43例(72眼)AOFVD患者和12例(24眼)Best‘s病患者进行研究。观察方法包括生物显微镜眼底检查、荧光素血管造影术(FA)、吲哚青绿血管造影术(ICGA)和光学相干断层扫描(OCT)。主要观察指标是对AOFVD在OCT断层图上的典型图像的描述，病变上的神经感觉性视网膜厚度之间的关系，以十进制表示的BCVA，以及与OCT在Best疾病中的描述的比较。结果：43例AOFVD患者中，29例为双眼黄斑病变。荧光血管造影术显示72只眼中65只眼中央低荧光点被不规则的高荧光环包围。吲哚青绿血管造影术显示27只眼中有22只眼中央无荧光斑点和中心斑点周围有强荧光区。在43名患者的72只眼中，OCT显示反射带中央有一个清晰的增厚区域，代表视网膜色素上皮。视网膜神经感觉层厚度与BCVA之间存在显著的相关性(P=.001，r(2)=0.61)。在Best病的所有24只眼中，光学相干断层扫描显示明确的中央浆液性视网膜脱离。结论：72只眼AOFVD的FA和ICGA表现不同。相反，OCT断层扫描显示所有眼睛的RPE都有明显的视网膜下增厚。血管造影有无弱荧光斑点的OCT图像无明显差异，有助于AOFVD的诊断。此外，在AOFVD病变上视网膜神经感觉层较薄的患者，视力明显下降。最后，OCT图像也有助于区分AOFVD和Best病。(C)2002年，爱思唯尔科学公司。保留所有权利。
.PURPOSE: The purpose of this article is to analyze cross,sectional images of a subretinal macular lesion, using optical coherence tomography (OCT) in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), to compare thickness of the neurosensory retina over the lesion with best-corrected visual acuity (BCVA) of each eye, and to compare OCT tomograms of AOFVD patients with OCT of Best disease..DESIGN: Observational case series..METHODS: This is a retrospective study which took place in a clinical practice. Forty,three patients (72 eyes) with AOFVD and 12 patients (24 eyes) with Best's disease were studied. The observation procedures used were biomicroscopic fundus examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT). The main outcome measures were a description of the typical picture of AOFVD in OCT tomograms, the relationship between the neurosensory retinal thickness over the lesion, the BCVA expressed in decimal terms, and a comparison with description of OCT in Best disease.. RESULTS: Of the 43 patients affected by AOFVD, 29 had bilateral macular lesions. Fluorescein angiography showed a central hypofluorescent spot surrounded by an irregular hyperfluorescent ring in 65 of the 72 eyes. Indocyanine green angiography demonstrated a central nonfluorescent spot and a hyperfluorescent area surrounding the central spot in 22 of 27 eyes examined. In all 72 eyes of 43 patients, OCT showed a well-defined central region of thickening in the reflective band representing the retinal pigment epithelium WE). The relationship between the thickness of neurosensory retina over the lesion and BCVA was significant (P =.001, r(2) = 0.61). Optical coherence tomography in all 24 eyes with Best disease showed a well-defined central serous retinal detachment.. CONCLUSION: In the 72 eyes with AOFVD, FA and ICGA presented different features. Instead, OCT tomograms showed a well defined subretinal thickening of the RPE in all the eyes. The lack of difference in OCT patterns between cases with or without the hypofluores cent spot on angiography was useful for confirming the diagnosis of AOFVD. Moreover, a reduced visual acuity was evident in patients with a thinner neurosensory retinal layer over AOFVD lesion. Finally, OCT images were also useful for distinguishing AOFVD from Best disease. (C) 2002 by Elsevier Science Inc. All rights reserved.