Use of cisplatin-containing biodegradable beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004)
Use of cisplatin-containing biodegradable beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004)
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DOI：
10.2460/javma.229.10.1617
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发表时间：
2006-11-15
影响因子：
1.9
通讯作者：
Sullins, Kenneth E.
中科院分区：
文献类型：
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作者：
Hewes, Christina A.;Sullins, Kenneth E.
目的：探讨含顺铂可生物降解微球单独或联合消肿治疗马科动物皮肤肿瘤的疗效。设计-回顾性案例系列。动物：56匹马，1匹斑马，1头驴和1头骡子。程序-审查了医疗记录。通过与这些动物的主人和驯兽师的电话交谈，获得了后续信息。结果：肉瘤22例，纤维肉瘤6例，纤维瘤1例，周围神经鞘肿瘤2例，鳞状细胞癌11例，黑色素瘤14例（灰马13例，月桂马1例），淋巴肉瘤1例，腺癌1例，基底细胞瘤1例。45只（76%）动物在植入头之前接受了常规或激光肿瘤切除术。48只有长期随访信息的动物中有40只（83%）在治疗2年后无复发。22只动物中有20只患有梭形细胞肿瘤（包括11/13匹患有肉瘤的马），10只动物中有6只患有鳞状细胞癌，14只动物中有13只患有黑色素瘤，3只动物中有2只患有其他肿瘤类型。副作用很小。结论：含顺铂可生物降解微球植入，不论有无肿瘤减积，都可能是治疗马科动物各种皮肤肿瘤的有效方法。
Objective-To determine outcome for equids with cutaneous neoplasms treated with cisplatin-containing biodegradable beads, alone or in conj. unction with debulking.Design-Retrospective case series.Animals-56 horses, 1 zebra, 1 donkey, and 1 mule.Procedures-Medical records were reviewed. Followup information was obtained through telephone conversations with owners and trainers of the animals.Results-22 tumors were sarcoids, 6 were fibrosarcomas, 1 was a fibroma, 2 were peripheral nerve sheath tumors, 11 were squamous cell carcinomas, 14 were melanomas (13 gray horses and 1 bay horse), I was a lymphosarcoma, I was an adenocarcinoma, and I was a basal cell tumor. Forty-five (76%) animals underwent conventional or laser debulking of the tumor prior to bead implantation. Forty of 48 (83%) animals for which long-term follow-up information was available were relapse free 2 years after treatment. This included 20 of 22 animals with spindle cell tumors (including 11/13 horses with sarcoids), 6 of 10 animals with squamous cell carcinomas, 13 of 14 animals with melanomas, and 2 of 3 animals with other tumor types. Adverse effects were minimal.Conclusions and Clinical Relevance-Results suggest that implantation of cisplatin-containing biodegradable beads, with or without tumor debulking, may be an effective treatment for equidae with various cutaneous neoplasms.