Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling.
Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling.
复制标题
I 型干扰素受体亚基胞质结构域在信号传导中的作用。
DOI：
10.1006/scbi.2000.0311
复制
发表时间：
2000
影响因子：
14.5
通讯作者：
Colamonici,OR
中科院分区：
文献类型：
--
作者：
Prejean,C;Colamonici,OR
Type I interferons are imperative in maintaining a defense against viral infection. These cytokines also play an important role in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. In the present article, we attempt to analyze the advances made in the last four years on type I interferon signaling. This review will focus on the contribution of the cytoplasmic domain of the α and β L chains of the receptor to the activation of the Jak-Stat pathway. We also analyze the possible role of other pathways in interferon signaling.
