Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques
Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques
复制标题
DOI：
10.1016/j.diabres.2012.01.004
复制
发表时间：
2012-05-01
影响因子：
5.1
通讯作者：
Lee, Kwan-Woo
中科院分区：
文献类型：
--
作者：
An, So-Yeon;Lee, Min Suk;Lee, Kwan-Woo
目的：成纤维细胞生长因子21（FGF 21）是糖/脂代谢的重要调节因子。虽然有研究检查血清FGF 21水平和葡萄糖稳态之间的关系，FGF 21的作用仍然不清楚。本研究的目的是检查血清FGF 21水平是否与不同程度的肥胖和糖耐量受试者的代谢参数以及与2型糖尿病（T2 DM）受试者的并发症相关。这项研究包括213名受试者，他们都是瘦人，葡萄糖耐量正常（瘦NGT）、超重伴NGT、糖耐量受损（IGT）或T2 DM。结果：T2 DM患者血清FGF 21水平明显高于瘦NGT患者（P < 0. 05），而瘦NGT患者血清FGF 21水平明显高于瘦NGT患者（P < 0. 05）。除T2 DM受试者外，所有受试者的血清FGF 21水平均与尿白蛋白/肌酐比值（ACR）呈正相关，T2 DM受试者在校正年龄、性别和体重指数后显示相关性。结论：血清FGF 21水平与尿ACR及糖尿病合并症（包括颈动脉斑块）有关。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Aims: Fibroblast growth factor 21 (FGF21) is an important regulator of glucose/lipid metabolism. Although there are studies examining the relationship between serum FGF21 levels and glucose homeostasis, the role of FGF21 remains unclear. The objective of this study was to examine whether serum FGF21 levels are associated with metabolic parameters in subjects with varying degrees of obesity and glucose tolerance and with complications in subjects with type2 diabetes mellitus (T2DM).Methods: The study consisted of 213 subjects who were lean and had normal glucose tolerance (lean NGT), were overweight with NGT, had impaired glucose tolerance (IGT) or had T2DM. Serum FGF21 levels and their associations with the parameters of adiposity, glucose tolerance and the presence of diabetic complications were examined.Results: The serum FGF21 levels in T2DM were higher than in lean NGT. Serum FGF21 levels showed a positive correlation with the urine albumin-to-creatinine ratio (ACR) in all subjects except for the T2DM subjects, who showed a correlation after adjustment of age, gender and body mass index. Moreover, the subjects with carotid artery plaque showed higher serum FGF21 levels than those without complications.Conclusion: Serum FGF21 levels were associated with the urine ACR and diabetic complications including carotid artery plaque. (C) 2012 Elsevier Ireland Ltd. All rights reserved.