Reference values for the arterial pulse wave in Chinese
Reference values for the arterial pulse wave in Chinese
复制标题
中文动脉脉搏波参考值。
DOI：
10.1038/ajh.2008.151
复制
发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Wang, J. G.
中科院分区：
文献类型：
--
作者：
Li, Yan;Staessen, Jan A.;Wang, J. G.
背景使用SPhygmoCor系统的脉搏波分析允许估计中心脉压(PP)以及外周和中枢增强指数(ALX)。方法从动脉指数与年龄相关的回归模型中计算出正常范围为95%可信区间。结果924例(男性50.7%，平均年龄40.7岁)无明显心血管疾病。与女性相比，男性的外周(43.3vs.41.7 mm Hg；P=0.0001)和中央性(32.9vs.30.9 mm Hg；P<；0.0001)PPS较高，但外周性(69.0vs.74.2%；P<；0.0001)和中央性(16.6vs.21.0%；P<；0.0001)ALX较低。各动脉测量值均随年龄增长呈曲线关系。调整混杂因素前后，男女外周和中枢PPS均有不同程度的增加(P=0.13)。在40岁的中国人中，外周性和中央性PPS、外周性和中央性ALX的近似阈值分别为58 mm Hg、48 mm Hg、105%和45%。考虑到20~60岁的年龄范围，外周和中枢PPS、外周和中枢ALX的阈值分别在5 mm Hg、10 mm Hg、20%和15%的范围内变化。结论本研究提供了中国人PP和ALX的初步诊断阈值，有待前瞻性研究的进一步验证。
BACKGROUND Pulse wave analysis using the SphygmoCor system allows the estimation of central pulse pressure (PP) and peripheral and central augmentation indexes (Alxs). We studied the limits of normality of these measurements in Chinese.METHODS We computed limits of normality as the 95% confidence boundaries from regression models relating the arterial indexes to age.RESULTS The reference population included 924 subjects (50.7% men, mean age 40.7 years) without overt cardiovascular disease. Men, compared to women, had higher peripheral (43.3 vs. 41.7 mm Hg; P = 0.01) and central (32.9 vs. 30.9 mm Hg; P < 0.0001) PPs, but lower peripheral (69.0 vs. 74.2%; P < 0.0001) and central (16.6 vs. 21.0%; P < 0.0001) Alxs. All arterial measurements showed a curvilinear relation with age. Both before and after adjustment for confounding factors, peripheral and central PPs increased less (P = 0.13) in both sexes. In 40-year-old Chinese, approximate thresholds for peripheral and central PPs, peripheral and central Alxs were 58 mm Hg, 48 mm Hg, 105% and 45%, respectively. Considering the age range from 20 to 60 years, thresholds varied within similar to 5 mm Hg, similar to 10 mm Hg, similar to 20%, and similar to 15% of the aforementioned thresholds for peripheral and central PPs, peripheral and central Alxs, respectively.CONCLUSIONS Pending further validation in prospective studies, our present study provides preliminary diagnostic thresholds for PP and Alxs in Chinese.