CHOLINERGIC MODULATION OF THE CONTENT OF TEMPORAL MEMORY
CHOLINERGIC MODULATION OF THE CONTENT OF TEMPORAL MEMORY
复制标题
DOI：
10.1037/0735-7044.101.4.457
复制
发表时间：
1987-08-01
影响因子：
1.9
通讯作者：
CHURCH, RM
中科院分区：
文献类型：
--
作者：
MECK, WH;CHURCH, RM
用20-S听觉信号峰间期程序研究了抗胆碱酯酶(毒扁豆碱和新斯的明)和胆碱能受体阻滞剂(阿托品和甲基阿托品)对大鼠短时记忆内容的药理作用。毒扁豆碱ip降低了时间分辨的变异性，并使峰时间在时间尺度上永久左移，呈剂量依赖性(0.01、0.03和0.09 mg/kg)。新斯的明(0.03 mg/kg)不产生上述任何作用。Ip阿托品增加了时间分辨的变异性，并使峰值时间在时间尺度上永久右移，呈剂量依赖关系(0.05、0.15和0.45 mg/kg)。甲基阿托品(0.15 mg/kg)不产生上述作用。标量计时模型的应用表明毒扁豆碱减少了强化记忆次数，增加了对时间的敏感性，而阿托品则增加了强化记忆次数，降低了时间敏感性。这些结果表明，脑乙酰胆碱的有效水平决定了将由内部时钟测量的持续时间转换为存储在时间记忆中的值的通信速度。
The pharmacological effects of anticholinesterases (physostigmine and neostigmine) and cholinergic receptor blockers (atropine and methylatropine) on the content of temperal memory in the rat were studied with the use of 20-s peak-interval procedure with auditory signals. Physostigmine administered ip decreased the variability of the temporal discrimination and shifted peak times permanently leftward on the time scale in a dose-dependent fashion (0.01, 0.03, and 0.09 mg/kg). Neostigmine (0.03 mg/kg) did not produce any of these effects. Atropine administered ip increased the variability of the temporal discrimination and shifted peak times permanently rightward on the time scale in a dose-dependent fashion (0.05, 0.15, and 0.45 mg/kg). Methylatropine (0.15 mg/kg) did not produce any of these effects. Application of a scalar timing model indicated that physostigmine decreased the remembered times of reinforcement and increased sensitivity to time, whereas atropine increased the remembered times of reinforcement and decreased sensitivity to time. These results suggest that the effective level of brain acetylcholine sets the communication speed for the translation of duration measured by internal clock into values stored in temporal memory.