New Developments in Neuroimmunology, Gut environment favors the induction of intraepithelial myelin-reactive CD4+ T cells that inhibit central nervous system autoimmunity through LAG-3.
New Developments in Neuroimmunology, Gut environment favors the induction of intraepithelial myelin-reactive CD4+ T cells that inhibit central nervous system autoimmunity through LAG-3.
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神经免疫学的新进展，肠道环境有利于诱导上皮内髓磷脂反应性 CD4 T 细胞，通过 LAG-3 抑制中枢神经系统自身免疫。
DOI：
10.1111/cen3.12377
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Atsushi Kadowaki
中科院分区：
文献类型：
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作者：
Kato T;Tanaka D;Muro S;Jambaljav B;Mori E;Yonemitsu S;Oki S;Inagaki N.;Atsushi Kadowaki
虽然已发现肠道环境显着影响多种免疫疾病，例如多发性硬化症，但人们对免疫细胞机制知之甚少。在这里，我总结了我们之前在《自然通讯》上发表的原创文章，描述了独特的调节性 T 细胞，这些细胞对于肠道环境控制中枢神经系统自身免疫可能很重要。
While the gut environment has been found to significantly influence various immunological diseases such as multiple sclerosis, immune cell mechanisms are poorly understood. Here, I summarized our original article previously published in Nature Communications, describing the unique regulatory T cells that may be important for the gut environment to control CNS autoimmunity.