Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod
Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod
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DOI：
10.1034/j.1601-183x.2003.00028.x
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发表时间：
2003-08-01
影响因子：
2.5
通讯作者：
Flaherty, L
中科院分区：
文献类型：
--
作者：
McFadyen, MP;Kusek, G;Flaherty, L
旋转棒通常用于评估小鼠的运动能力。我们研究了一些近交系，以确定是否有转棒性能和运动学习的遗传变异。小鼠在改良的加速旋转杆范例中每天接受三次试验，持续三天，并且计算每天的主动旋转性能。测试了雄性和雌性129 S1/SvImJ、A/J、BALB/cByJ、C3 H/HeJ、C57 BL/6 J、CBA/J、DBA/2 J和FVB/NJ小鼠。在运动成绩上观察到应变和性别差异。运动学习在不同菌株之间也存在差异，因为一些菌株在三天内表现出性能的改善，而其他菌株则没有。在某些品系中，小鼠的体重和体长与转棒性能相关。通过比较C3 H/HeJ小鼠（具有视网膜变性）和同类C3 A. BLiA-Pde 6 b（+）（Pdeb+）小鼠（没有视网膜变性）来评估视觉在旋转杆上的运动表现中的作用。视力受损的C3 H小鼠在转棒上停留的时间比它们的视力正常的Pdeb+伴侣长，尽管两种品系在几天内都有所改善。因此，我们已经证明了旋转棒表现中的遗传因素，并且我们已经证明除了固有运动能力之外的因素也可以影响小鼠的旋转棒表现。
The rotorod is commonly used to assess motor ability in mice. We examined a number of inbred strains to determine whether there is genetic variability in rotorod performance and motor learning. Mice received three trials per day for three days in a modified accelerating rotorod paradigm, and active rotation performance was calculated for each day. Male and female 129S1/SvImJ, A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J and FVB/NJ mice were tested. Strain and sex differences were observed in motor performance. Motor learning also differed across strains, as some strains showed an improvement in performance over the three days while other strains did not. In certain strains the weight and body length of the mouse correlated with rotorod performance. The role of vision in motor performance on the rotorod was assessed by a comparison of C3H/HeJ mice (with retinal degeneration) and congenic C3A.BLiA-Pde6b(+) (Pdeb+) mice (without retinal degeneration). The sight-impaired C3H mice stayed on the rotorod longer than did their sighted Pdeb+ partners, although both strains improved across days. Thus, we have demonstrated a genetic component in rotorod performance, and we have shown that factors other than inherent motor ability can contribute to rotorod performance in mice.