Functional relationship between human rolandic oscillations and motor cortical excitability: an MEG study
Functional relationship between human rolandic oscillations and motor cortical excitability: an MEG study
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DOI：
10.1111/j.1460-9568.2005.04096.x
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发表时间：
2005-05
影响因子：
3.4
通讯作者：
Y. Tamura;M. Hoshiyama;H. Nakata;N. Hiroe;K. Inui;Y. Kaneoke;Kiyoharu Inoue;R. Kakigi
中科院分区：
文献类型：
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作者：
Y. Tamura;M. Hoshiyama;H. Nakata;N. Hiroe;K. Inui;Y. Kaneoke;Kiyoharu Inoue;R. Kakigi
大脑中神经节律的同步化和去同步化在知觉、运动动作和意识体验的协调中起着重要的作用。根据皮层和脑磁图(MEG)记录的结果，认为人类的滚动性振荡起源于中央沟前岸(20-Hz节律)和中央后皮质(10-Hz节律)：20-Hz振荡与运动功能密切相关，而10-Hz节律主要归因于感觉功能。为了测试罗兰德振荡是否与运动皮质兴奋性有关，我们观察了12名正常受试者左侧初级运动皮质(M1)1赫兹重复经颅磁刺激(RTMS)对运动相关罗兰德振荡的影响。比较右手食指快速伸展时的脑磁图数据在两个不同的训练阶段(使用和不使用rTMS条件反射)。同时检测rTMS前后右手肌肉的运动诱发电位(MEP)，以评估运动皮质的兴奋性。我们发现，M1上的1赫兹rTMS显著降低了运动相关的20赫兹振荡的反弹，并伴随着运动皮质兴奋性的降低。特别是，与运动相关的20赫兹节律的反弹与运动皮质的兴奋性密切相关。这些发现进一步加强了20赫兹皮质振荡与运动皮质兴奋性的功能相关性的概念。在前人研究的框架下，运动相关反弹的减少可能被认为是对大脑皮质活动抑制的代偿反应。
Synchronization and desynchronization of the neural rhythm in the brain play an important role in the orchestration of perception, motor action and conscious experience. Based on the results of electrocorticographic and magnetoencephalographic (MEG) recordings, it has been considered that human rolandic oscillations originate in the anterior bank of the central sulcus (20‐Hz rhythm) and the postcentral cortex (10‐Hz rhythm): the 20‐Hz oscillation is closely related to motor function, while the 10‐Hz rhythm is attributed mainly to sensory function. To test whether the rolandic oscillations are functionally relevant to the motor cortical excitability, we examined effects of 1‐Hz repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) on movement‐related changes of the rolandic oscillations in 12 normal subjects. MEG data recorded during brisk extension of the right index finger in two different sessions (with and without rTMS conditioning) were compared. Motor‐evoked potential (MEP) of the right hand muscle was also measured before and after rTMS to assess the motor cortical excitability. We found that 1‐Hz rTMS over M1 significantly reduced the movement‐related rebound of the 20‐Hz oscillation in association with decreased motor cortical excitability. In particular, movement‐related rebound of the 20‐Hz rhythm was closely tied with motor cortical excitability. These findings further strengthen the notion of functional relevance of 20‐Hz cortical oscillation to motor cortical excitability. In the framework of previous studies, the decrease in movement‐related rebound may be regarded as a compensatory reaction to the inhibited cortical activity.