Association of a Methylene Tetrahydrofolate Reductase C677T Polymorphism with Several Blood Chemical Levels in a Chinese Population
Association of a Methylene Tetrahydrofolate Reductase C677T Polymorphism with Several Blood Chemical Levels in a Chinese Population
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亚甲基四氢叶酸还原酶 C677T 多态性与中国人群几种血液化学水平的关联
DOI：
10.1089/gtmb.2014.0213
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发表时间：
2015
影响因子：
1.4
通讯作者：
Wang Xiao-Zhong
中科院分区：
文献类型：
--
作者：
Wen Can;Lv Jiao-Feng;Wang Ling;Zhu Wei-Feng;Wan Fu-Sheng;Wang Xiao-Zhong
研究背景亚甲基四氢叶酸还原酶（MTHFR）基因C677 T多态性与某些人群的高血压相关。本研究探讨MTHFR基因多态性与高血压及相关血脂指标的关系，包括同型半胱氨酸（HCY）、脂蛋白（a）[Lp（a）]、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A I（Apo AI）、载脂蛋白B、血糖（GLU）、总胆固醇（TC）、甘油三酯（TG），材料与方法2012年6月至2012年9月，在江西省招募了174例高血压患者和634例健康对照者，采用聚合酶链反应技术对MTHFRC 677 T多态性进行基因分型。限制性片段长度多态性。生化参数也进行了评估，在这些科目和统计学比较，以theMTHFRC 677 T多态性和高血压的风险。ResultsHCY和Lp（a）水平显着较高的受试者与MTHFR 677 TT基因型比CC/CT基因型，独立的高血压。高血压病组TT基因型和T等位基因频率显著高于对照组。男性高血压患者组HCY、HDL、ApoAI、TC的平均水平与女性高血压患者组相比差异有显著性（pHCY= 0.001，pHDL = 0.004，pApoAI <0.001，pTC =0.012）。在男性对照组中，HCY、HDL、ApoAI、GLU和TC的平均水平与女性对照组有显著差异（pHCY<0.001，pHDL <0.001，pApoAI <0.001，pGLU =0.001，pTC =0.004）。男女高血压患者与对照组血脂相关指标存在差异。
BackgroundThe methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with hypertension in certain populations. This study investigated the relationship between theMTHFRpolymorphism and hypertension and correlated blood lipid indexes, including homocysteine (HCY), lipoprotein (a) [Lp (a)], high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A I (Apo AI), Apo B, glucose (GLU), total cholesterol (TC), and triglyceride (TG), in a Chinese population.Materials and MethodsA total of 174 patients with hypertension and 634 healthy control individuals from Jiangxi Province were recruited between June 2012 and September 2012 for genotyping of theMTHFRC677T polymorphism using polymerase chain reaction-restriction fragment length polymorphism. Biochemical parameters were also assessed in these subjects and statistically compared to theMTHFRC677T polymorphism and the risk for hypertension.ResultsHCY and Lp (a) levels were significantly higher in subjects with aMTHFR677TT genotype than in those with a CC/CT genotype, independent of hypertension. The frequency of the TT genotype and the T allele in hypertension patients was significantly higher than in the healthy controls. Furthermore, in the male hypertension patient group, the average levels of HCY, HDL, Apo AI, and TC were significantly different from those in female hypertension patients (pHCY=0.001,pHDL=0.004,pApo AI<0.001,pTC=0.012). In the male control group, the average levels of HCY, HDL, Apo AI, GLU, and TC were significantly different from those of female controls (pHCY<0.001,pHDL<0.001,pApo AI<0.001,pGLU=0.001, andpTC=0.004).ConclusionOur data demonstrate that theMTHFRC677T polymorphism is positively correlated with an increased risk of hypertension through an increase in HCY levels. The blood lipid correlative index was different between male and female hypertension patients and controls.