Functional versus phenotypic analysis of T cells in subjects seropositive for the human immunodeficiency virus: a prospective study of in vitro responses to Cryptococcus neoformans.
Functional versus phenotypic analysis of T cells in subjects seropositive for the human immunodeficiency virus: a prospective study of in vitro responses to Cryptococcus neoformans.
复制标题
人类免疫缺陷病毒血清阳性受试者 T 细胞的功能与表型分析：对新型隐球菌体外反应的前瞻性研究。
DOI：
10.1093/infdis/158.5.1071
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Miller,GG
中科院分区：
文献类型：
--
作者：
Hoy,JF;Lewis,DE;Miller,GG
We performed a prospective study of 50 subjects at high risk for human immunodeficiency virus (HIV) infection to determine if assays of antigen-specific T cell function provide an earlier indication of future progression to AIDS or a better assessment of immune function than do current methods of evaluation. Wemeasured in vitro T cell responses toCryptococcus neoformansand tetanus toxoid, response to mitogens, HIV p24 antigenemia, and clinical parameters. Progression to AIDS was significantly associated with loss of T cell response to cryptococci (P= .015), HIV antigenemia (P= .001), and low CD4+cell numbers (P= .001). Most importantly, we found that loss of antigen-specific responses to cryptococci and tetanus can occur before changes in CD4 cell number. Abnormal response to mitogens and marked depletion of CD4+cells were late signs of progressive HIV infection. Measurement of antigen-specific T cell function may be useful for assessing the efficacy of antiviral therapy in HIV infection before onset of symptoms.
