DIFFERENT CLINICOPATHOLOGICAL FINDINGS IN 2 HISTOLOGIC TYPES OF CARCINOMA OF PAPILLA OF VATER
DIFFERENT CLINICOPATHOLOGICAL FINDINGS IN 2 HISTOLOGIC TYPES OF CARCINOMA OF PAPILLA OF VATER
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DOI：
10.1111/j.1349-7006.1994.tb02077.x
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发表时间：
1994-02-01
期刊：
影响因子：
--
通讯作者：
ESAKI, Y
中科院分区：
文献类型：
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作者：
KIMURA, W;FUTAKAWA, N;ESAKI, Y
本研究的目的是探讨两种组织学类型的乏特乳头癌的临床病理特征之间的差异。我们在组织学上将乳头状癌分为两种类型：1）肠型，类似于胃或结肠的管状腺癌; 2）胰胆管型，其特征在于乳头状突起，纤维核心很少。我们检查了53例乳头癌切除。肠型癌与肠粘膜相似，因为它们具有含溶菌酶的潘氏或嗜银细胞，如抗溶菌酶抗体的化学染色阳性所示。虽然两种类型癌的大小和年龄分布基本相同，但肠型癌的预后明显好于胰胆型癌。组织学淋巴结转移在胰胆型中明显更常见。这一结果得到了以下事实的支持：肠型小癌很少或没有浸润到周围的淋巴结，而胰胆型则有很强的浸润倾向。考虑到这两种组织学类型的存在，乏特乳头癌的发病机制应进一步评估。
The aim of this study was to investigate the differences between the clinicopathological findings in two histologic types of carcinoma of the papilla of Vater. We histologically classified carcinoma of the papilla into two types: 1) an intestinal type that resembles tubular adenocarcinoma of the stomach or colon, and 2) a pancreaticobiliary type that is characterized by papillary projections with scant fibrous cores. We examined 53 cases of resected carcinoma of the papilla. The intestinal-type carcinomas were similar to the intestinal mucosa in that they had lysozyme-containing, Paneth or argyrophil cells, as demonstrated by the immunohistochemically positive stainings for the anti-lysozyme antibody. Although both the sizes of the two types of carcinomas and the age distributions of cases with the two types of carcinoma were almost the same, the prognosis of the cases with the intestinal type was much better than that of the cases with the pancreaticobiliary type. Histological lymph node metastasis was found significantly more often in the pancreaticobiliary type. This result was supported by the fact that small carcinomas of the intestinal type showed little or no invasion into the surrounding interstitium, as opposed to the pancreaticobiliary type, which had a strong infiltrative tendency. The pathogenesis of carcinoma of the papilla of Vater should be further evaluated, taking into consideration the existence of these two histologic types.