Incidence of severe rotavirus diarrhea in New Delhi, India, and G and P types of the infecting rotavirus strains
Incidence of severe rotavirus diarrhea in New Delhi, India, and G and P types of the infecting rotavirus strains
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DOI：
10.1086/431497
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发表时间：
2005-09-01
影响因子：
6.4
通讯作者：
Bhan, MK
中科院分区：
文献类型：
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作者：
Bahl, R;Ray, P;Bhan, MK
通过被动监测对来自印度新德里贫民窟的50万名儿童和成人中的62，475名5岁以下儿童进行了为期1年的评估，以确定因腹泻住院的儿童。估计轮状病毒严重腹泻的发生率，确定感染轮状病毒的G型和P型，并与腹泻的临床严重程度相关。在584名因腹泻住院的儿童中，137名（23.5%）在粪便标本中检测到轮状病毒（轮状病毒腹泻相关住院的发生率，337例住院/100，000名5岁以下儿童）。大多数腹泻病例（98%）发生在生命的前2年，在9 - 11个月大时达到高峰。轮状病毒相关性腹泻全年发生，但主要发生在冬季。在可能是G型的菌株中，G1是最常见的血清型，其次是G9和G2; 10%的腹泻病例是由于混合G型感染。本监测研究中鉴定的常见菌株为P[8]G1、P[4]G2、P[8]G9、P[6]G1、P[6]G9和P[6]G3。感染G1毒株的儿童比感染其他轮状病毒毒株的儿童发生更严重腹泻病例的风险更大（比值比，2.95; 95%置信区间，1.3 - 6.67）。
A total of 62,475 children < 5 years old from a defined population of similar to 500,000 children and adults from slums in New Delhi, India, were assessed for 1 year by means of passive surveillance, to identify children who were hospitalized for diarrhea. The incidence of severe rotavirus diarrhea was estimated, and the G and P types of the infecting rotavirus strains were determined and were correlated with the clinical severity of diarrhea. Of 584 children who were hospitalized with diarrhea, 137 (23.5%) had rotavirus detected in stool specimens (incidence of rotavirus diarrhea-associated hospitalizations, 337 hospitalizations/100,000 children < 5 years of age). Most cases of diarrhea (98%) occurred during the first 2 years of life, peaking at 9 - 11 months of age. Rotavirus-associated diarrhea occurred year-round but was predominant in winter. Among the strains that could be G-typed, G1 was the most common serotype, followed by G9 and G2; 10% of cases of diarrhea were due to mixed G-type infections. Common strains identified in the present surveillance study were P[8]G1, P[4]G2, P[8]G9, P[6]G1, P[6]G9, and P[6]G3. Children infected with G1 strains had a greater risk of developing more-severe cases of diarrhea than did children infected with other rotavirus strains (odds ratio, 2.95; 95% confidence interval, 1.3 - 6.67).