Reasons why DBA/2 mice are resistant to malarial infection: expansion of CD3int B220+ gammadelta T cells with double-negative CD4- CD8- phenotype in the liver.
Reasons why DBA/2 mice are resistant to malarial infection: expansion of CD3int B220+ gammadelta T cells with double-negative CD4- CD8- phenotype in the liver.
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发表时间：
2006
期刊：
影响因子：
6.4
通讯作者：
H. Bakir;C. Tomiyama-Miyaji;Hisami Watanabe;T. Nagura;T. Kawamura;H. Sekikawa;T. Abo
中科院分区：
文献类型：
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作者：
H. Bakir;C. Tomiyama-Miyaji;Hisami Watanabe;T. Nagura;T. Kawamura;H. Sekikawa;T. Abo
DBA/2 （H-2(d)）小鼠比C57BL/6 （B6, H-2(b)）小鼠对非致死性约氏疟原虫17XNL株的抗性更强。这是一个非常奇怪的现象，因为已知DBA/2小鼠的常规T细胞，特别是CD8(+) T细胞的功能略低于其他品系的小鼠。我们在此研究了DBA/2小鼠和B6小鼠在疟疾感染期间的免疫反应差异。与B6小鼠相比，DBA/2小鼠和（DBA/2 × B6）F(1) (BDF（1), H-2(b/d)）小鼠具有较轻的寄生虫血症，并且从疟疾感染中恢复得更快。这些DBA/2和BDF(1)小鼠还发现肝脏中白细胞介素(IL)-2Rbeta(+) CD3（int）细胞和γ - T细胞显著增加，特别是在恢复阶段。非常规T细胞（即B220(+) T细胞）在DBA/2和BDF(1)小鼠中也有扩增。B220(+) T细胞以γ - T细胞为主，CD4（-）和CD8（-）双阴性。更重要的是，DBA/2和BDF(1)小鼠的免疫球蛋白M （IgM）型抗dna自身抗体的产生也高于B6小鼠。结合细胞因子产生的数据，这些结果表明原始T细胞和B细胞，即自身反应性胸腺外T细胞和自身抗体产生B细胞，可能在DBA/2小鼠中更活跃，因此对非致死性约氏疟原虫17XNL株具有抗性。
DBA/2 (H-2(d)) mice are known to be more resistant than C57BL/6 (B6, H-2(b)) mice to the non-lethal 17XNL strain of Plasmodium yoelii. This is a very strange phenomenon because the functions of conventional T cells, especially CD8(+) T cells, are known to be somewhat lower in DBA/2 mice than in other strains of mice. We examined herein how immune responses differed between DBA/2 mice and B6 mice during malarial infection. DBA/2 mice and (DBA/2 x B6)F(1) (BDF(1), H-2(b/d)) mice were found to have milder parasitaemia and to recover more quickly from malarial infection than B6 mice. These DBA/2 and BDF(1) mice were also found to experience a marked expansion of interleukin (IL)-2Rbeta(+) CD3(int) cells and gammadelta T cells in the liver, especially in the recovery phase. The expansion of unconventional T cells (i.e. B220(+) T cells) was also marked in DBA/2 and BDF(1) mice. The majority of B220(+) T cells were gammadelta T cells and these T cells were double-negative CD4(-) CD8(-). More importantly, the production of immunoglobulin M (IgM)-type anti-DNA autoantibody was also higher in DBA/2 and BDF(1) mice than in B6 mice. In conjunction with data on cytokine production, these results indicate that primitive T and B cells, namely autoreactive extrathymic T cells and autoantibody-producing B cells, may be much more activated in DBA/2 mice and therefore resistant to the non-lethal 17XNL strain of P. yoelii.