Biological production of (S)-acetoin: a state-of-the-art review.
Biological production of (S)-acetoin: a state-of-the-art review.
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DOI：
10.2174/1568026619666191018111424
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发表时间：
2019
影响因子：
3.4
通讯作者：
N. Xie;Jianxiu Li;R. Huang
中科院分区：
文献类型：
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作者：
N. Xie;Jianxiu Li;R. Huang
乙偶姻是一种重要的四碳化合物，在食品、化学合成、化妆品、香烟、肥皂和洗涤剂中有许多应用。它的立体异构体（S）-乙偶姻是一种高价值的手性化合物，也可用于合成光学活性药物，提高靶向性，减少副作用。近年来，生物技术路线生产（S）-乙偶姻的研究取得了很大进展。本文综述了生物合成（S）-乙偶姻的各种方法，并对其局限性和可能的解决方案进行了描述。并对生物法生产（S）-乙偶姻的前景进行了展望。
Acetoin is an important four-carbon compound that has many applications in foods, chemical synthesis, cosmetics, cigarettes, soaps, and detergents. Its stereoisomer (S)-acetoin, a high-value chiral compound, can also be used to synthesize optically active drugs, which could enhance targeting properties and reduce side effects. Recently, considerable progress has been made in the development of biotechnological routes for (S)-acetoin production. In this review, various strategies for biological (S)-acetoin production are summarized, and their constraints and possible solutions are described. Furthermore, future prospects of biological production of (S)-acetoin are discussed.