Weak measurement-based sensor for the rapid identification of L(+)-ascorbic acid and D(-)-isoascorbic acid
Weak measurement-based sensor for the rapid identification of L(+)-ascorbic acid and D(-)-isoascorbic acid
复制标题
DOI：
10.1364/ao.58.008583
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yanhong Ji
中科院分区：
文献类型：
--
作者：
Suyi Zhong;Tian Gu;Yang Xu;Chongqi Zhou;Lixuan Shi;Cuixia Guo;Xuesi Zhou;Zhangyan Li;Yonghong He;Yanhong Ji
The ability to identify L(+)-ascorbic acid from D(-)-isoascorbic acid in medicinal products is of practical interest. Based on the method of frequency domain weak measurement, a set of common optical path sensors for identification of L(+)-ascorbic acid and D(-)-isoascorbic acid is established. By quantificationally analyzing the magnitude and offset direction of the spectral central wavelength, a good identification of the concentration and the optically active forms of ascorbic acid has been achieved. The sensitivity and resolution of the sensor for optical rotation can reach 34.35 nm/° and ${5.53} times {{10}^{ - 5}}^circ $5.53×10-5∘, respectively. The detection resolution for L(+)-ascorbic acid is ${2.00} times {{10}^{ - 4}};{rm mol}/{rm mL}$2.00×10-4mol/mL, and that for D(-)-isoascorbic acid is ${2.73} times {{10}^{ - 4}};{rm mol}/{rm mL}$2.73×10-4mol/mL. The potential of the sensor in the detection of transparent but optically inactive impurities has been verified by comparative experiments of sodium chloride solution. The sensor also has been applied to identify medicinal vitamin C tablets, which verified the feasibility of the method in optically active pharmaceutical solutions with water-insoluble, optically inactive impurities. Since the sensor has the advantages of high precision, real-time, high robustness, and being non-destructive, it has a great prospect in the field of drug detection containing chiral molecules.
