Therapeutic Potential of Natural Killer Cells in gastric cancer
Therapeutic Potential of Natural Killer Cells in gastric cancer
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DOI：
10.3389/fimmu.2018.03095
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发表时间：
2019
影响因子：
7.3
通讯作者：
Yongchang Wei
中科院分区：
文献类型：
--
作者：
Yu Du;Yongchang Wei
Gastric cancer (GC) is one of the most common cancers, with a high incidence of.cancer death. Despite various therapeutic approaches, the cures and prognosis of.advanced GC remain poor. Natural killer (NK) cells, which are known as important.lymphocytes in innate immunity, play vital roles in suppressing GC initiation, progression,.and metastases. A wide range of clinical settings shows that increasing the number of NK.cells or improving NK cell antitumor activity is promising in GC patients. NK cell adoptive.therapy (especially expanded NK cells) is a safe and well-tolerated method, which can.enhance NK cell cytotoxicity against GC. Meanwhile, cytokines, immunomodulatory.drugs, immune checkpoint blockades, antibodies, vaccines, and gene therapy have been.found to directly or indirectly activate NK cells to improve their killing activity toward GC..In this review, we summarize recent advancements in the relationship between NK cells.and GC and point out all the innovative strategies that can enhance NK cells’ function to.inhibit the growth of GC.
