The role of Tim-3 in regulating T cell exhaustion in cancer.

Tim-3 在调节癌症 T 细胞耗竭中的作用。

• 批准号: 203374
• 负责人: Rangachari Manu
• 金额: $ 7.29万
• 依托单位: The Brigham and Women's Hospital, Inc. (Boston)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2012-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=203374&lang=en
• 关键词: Colorectal Cancer; Hla-B Transcript 3 (Bat3); Interferon (Ifn)Gamma; Interleukin(Il)-2; T Cell Exhaustion; T Cell Immunoglobulin And Mucin Domain-Containing-3 (Tim-3); Th1 And Tc1 Cells; Tumour Immunity; Tumour Necrosis Factor (Tnf)Alpha

T cells of the immune system play a critical role in detecting and combating cancer. Unfortunately, T cells can develop a condition known as exhaustion, in which their immune functions become highly compromised over time. Therapies that reverse T cell exh

免疫系统的T细胞在检测和抗击癌症方面发挥着关键作用。不幸的是，T细胞可能会发展成一种称为衰竭的状态，在这种情况下，随着时间的推移，他们的免疫功能会高度受损。逆转T细胞exh的治疗方法