Effects and Mechanisms of B7-H4 Pathway on Inhibition of the Development of Type 1 Diabetes

B7-H4通路抑制1型糖尿病发展的作用及机制

• 批准号: 200938
• 负责人: Warnock Garth L
• 金额: $ 27.75万
• 依托单位: Vancouver Coastal Health Research Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2013-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200938&lang=en
• 关键词: B7-H4 Knockout Mice; B7-H4 Protein; B7-H4 Transgenic Mice; Inhibition Of The Development Of T1d; Negative Co-Signaling Pathway; Type 1 Diabetes

Type 1 diabetes is an autoimmune disease in which the cells of the pancreas that secrete insulin, called beta cells, are destroyed by the patient's own immune system. Despite decades of research, we are still not able to prevent or reverse this disease pr

1型糖尿病是一种自身免疫性疾病，在这种疾病中，胰腺中分泌胰岛素的细胞（称为β细胞）被患者自身免疫系统破坏。尽管经过了几十年的研究，我们仍然无法预防或逆转这种疾病