A modelling challenge: bridging the gap between molecular and neuronal networks

建模挑战：弥合分子网络和神经元网络之间的差距

• 批准号: DP1096083
• 负责人: Dr Nicolangelo Iannella
• 金额: $ 18.7万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-07-15 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096083
• 关键词: modelling; challenge; bridging; gap; between

We will develop innovative frameworks, which unify small-scale molecular activity with electrical signals in branches of brain cells. This research aims to enhance our understanding how molecular scale phenomena influence brain disease, via studying the model dynamics using cutting-edge techniques on a supercomputer. The socio-economic benefits to Australia include: (i) Enhancing Australia's international reputation for cutting-edge multidisciplinary research; (ii) international collaborations will be strengthened; (iii) outcomes will potentially lead to commercialisation opportunities; (iv) results will ultimately lay the foundations to explore the cellular and molecular origin of brain disorders.

我们将开发创新的框架，将小规模分子活动与脑细胞分支中的电信号统一起来。这项研究旨在通过在超级计算机上使用尖端技术研究模型动力学，增强我们对分子尺度现象如何影响大脑疾病的理解。对澳大利亚的社会经济效益包括：（i）提高澳大利亚在尖端多学科研究方面的国际声誉;（ii）国际合作将得到加强;（iii）成果将有可能带来商业化机会;（iv）成果将最终为探索大脑疾病的细胞和分子起源奠定基础。