Molecular mechanisms underlying the in utero origins of hypercholesterolemia

高胆固醇血症子宫内起源的分子机制

• 批准号: 211136
• 负责人: Hardy Daniel B
• 金额: $ 26.57万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=211136&lang=en
• 关键词: Cholesterol; Chomatin Immunoprecipitation (Chip); Epigenetics; Fetal Programming; Intervention Study; Liver; Liver X Receptor (Lxr); Nuclear Receptors; Posttranslational Histone Modifications; Sexual Dimorphism

While genetics,lifestyle, and diet contribute to the development of impaired liver function, elevated cholesterol, and cardiovascular disease (CVD), emerging epidemiological evidence also suggests that these abnormalities are also inversely related to imp

虽然遗传、生活方式和饮食有助于肝功能受损、胆固醇升高和心血管疾病（CVD）的发展，但新出现的流行病学证据也表明，这些异常也与imp呈负相关。