Reduced Force of the Heartbeat in CHF: Dysfunctional Ca2+ Transport due to loss of transverse tubules.

CHF 中心跳强度减弱：由于横小管缺失导致 Ca2+ 运输功能障碍。

• 批准号: 227561
• 负责人: Ter Keurs Hendrik E
• 金额: $ 7.29万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=227561&lang=en
• 关键词: Congestive Heart Failure; Fluorescent Ca2+ Imaging And High Speed Confocal Microscopy; Ischemic Heart Disease; Laser Diffraction Studies Of Cardiac Sarcomere Mechanics; Myocardium; Systolic Dysfunction

This research proposes to study why, after damage to the heart leading to heart failure, the heart beat is weaker and slower. The heart beat is turned-on by an electrical impulse, which starts in pace maker cells and travels along the surface membrane of

这项研究旨在研究为什么心脏受损导致心力衰竭后，心脏跳动更弱，更慢。 心脏跳动是由电脉冲启动的，电脉冲始于起搏细胞，并沿着细胞表面膜传播。