Improved membrane permeation assays for drug bioavailability assessment

肠道吸收差是药物发现的主要瓶颈，因为有前途的新化学实体通常缺乏吸收所需的合适的两亲性平衡。没有人知道有多少可接受的候选人已经从发现管道中被丢弃

Poor intestinal absorption is a major bottleneck in drug discovery as promising new chemical entities often lack suitable amphiphilic balance required for absorption. No one knows how many acceptable candidates have been discarded from the discovery pipel