Using solution NMR approaches to examine the structure and dynamics of ubiquitylated nucleosome core particles to understand their role in histone methylation and leukemogenesis.

使用溶液核磁共振方法检查泛素化核小体核心颗粒的结构和动力学，以了解它们在组蛋白甲基化和白血病发生中的作用。

• 批准号: 214230
• 负责人: Kitevski-Leblanc Julianne L
• 金额: $ 9.83万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-10-01 至 2013-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=214230&lang=en
• 关键词: Epigenetics; Functional Dynamics; Histone Proteins; Methyltrasferase Enzyme; Nuclear Magnetic Resonance Spectroscopy; Nucleosome Core Particle; Protein Structure

Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have recently been linked to specific chemical modifications of histone proteins. Histone proteins (H2A, H2B, H3 and H4) interact with DNA to form nucleosomes, the basic unit of structur

急性髓性白血病（AML）和急性淋巴细胞白血病（ALL）最近已与组蛋白的特定化学修饰有关。 组蛋白（H2A，H2B，H3和H4）与DNA相互作用形成核小体，核小体是结构的基本单位。