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Using solution NMR approaches to examine the structure and dynamics of ubiquitylated nucleosome core particles to understand their role in histone methylation and leukemogenesis.

Using solution NMR approaches to examine the structure and dynamics of ubiquitylated nucleosome core particles to understand their role in histone methylation and leukemogenesis.
使用溶液核磁共振方法检查泛素化核小体核心颗粒的结构和动力学，以了解它们在组蛋白甲基化和白血病发生中的作用。
批准号：
214230
负责人：
Kitevski-Leblanc Julianne L
金额：
$9.83万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-10-01 至 2013-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=214230&lang=en
关键词：
Epigenetics Functional Dynamics Histone Proteins Methyltrasferase Enzyme Nuclear Magnetic Resonance Spectroscopy Nucleosome Core Particle Protein Structure

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Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have recently been linked to specific chemical modifications of histone proteins. Histone proteins (H2A, H2B, H3 and H4) interact with DNA to form nucleosomes, the basic unit of structur
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