Biochemistry of tropoelastin: functional analysis of an essential cell-interactive domain

原弹性蛋白的生物化学：重要细胞相互作用域的功能分析

• 批准号: DP1096608
• 负责人: Prof Anthony Weiss
• 金额: $ 31.35万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-31 至 2013-01-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096608
• 关键词: Biochemistry; tropoelastin; functional; analysis; essential

Elastin is ten times more durable than the best man-made synthetic rubbers because our bodies need to control life-threatening rips in skin, artery and lung. Warm-blooded animals use elastin to build diversely shaped elastic materials for multiple biological environments in these tissues. In this project, we will learn a lot more about the most preserved and functional part of elastin. These discoveries will increase our understanding of the grand architectural rules by which elastic protein-based structures are made. We will learn new ways to manage cell interactions in an elastic environment and define design rules to assist in the future design of new cell-binding, elastic, composite materials.

弹性蛋白比最好的人造合成橡胶耐用十倍，因为我们的身体需要控制皮肤、动脉和肺中危及生命的撕裂。温血动物利用弹性蛋白在这些组织中构建不同形状的弹性材料，以适应多种生物环境。在这个项目中，我们将更多地了解弹性蛋白中保存最完整和功能最强大的部分。这些发现将增加我们对构成弹性蛋白质结构的宏伟建筑规则的理解。我们将学习在弹性环境中管理细胞相互作用的新方法，并定义设计规则，以协助未来设计新的细胞结合，弹性复合材料。