Role of progranulin in the TDP-43/FUS pathway in Amyotrophic Lateral Sclerosis (ALS) pathogenesis

颗粒体蛋白前体在 TDP-43/FUS 通路中在肌萎缩侧索硬化症 (ALS) 发病机制中的作用

• 批准号: 226522
• 负责人: Aroonassala Patten Shunmoogum
• 金额: $ 6.56万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-02-01 至 2013-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=226522&lang=en
• 关键词: Amyotriophic Lateral Sclerosis (Als); Gene Interactions And Cell Signaling; Gene Knockdown Technology; Motor Neurons; Zebrafish Als Model

To understand the role of genes (PGRN, TDP-43, FUS) linked to amyotrophic lateral sclerosis (ALS). I will investigate the role of the PGRN and its genetic interaction with TDP-43 and FUS which have recently been linked to ALS. Analysis of the role of PGRN

了解与肌萎缩侧索硬化症（ALS）相关的基因（PGRN，TDP-43，FUS）的作用。我将研究PGRN的作用及其与TDP-43和FUS的遗传相互作用，这些基因最近与ALS有关。PGRN的作用分析