Target identification of novel growth inhibitors for the multiple antibiotic resistant Burkholderia cenocepacia through genome-wide conditional growth expression

通过全基因组条件生长表达目标鉴定多重抗生素耐药性新洋葱伯克霍尔德杆菌的新型生长抑制剂

• 批准号: 234125
• 负责人: Cardona Silvia T
• 金额: $ 6.67万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-03-01 至 2013-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=234125&lang=en
• 关键词: Antibacterial Target; Antibiotic Mechanism Of Action; Bacterial Conditional Growth Mutant Library; Bacterial Transposon Mutageneis; Burkholderia Cenocepacia; High Throughput Screening; Multiplex Pcr; Next Generation Sequencing; Novel Antibiotics; Small Mo

The Burkholderia cepacia complex (Bcc) is a group of multiple antibiotic resistant bacteria that infect cystic fibrosis patients. Once established, the infection is virtually impossible to eradicate. For this reason, new and more effective antibiotics are

洋葱伯克霍尔德菌复合体（Bcc）是一组感染囊性纤维化患者的多重抗生素耐药细菌。一旦确定，感染几乎是不可能根除的。因此，新的和更有效的抗生素正在