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Identification and characterization of novel substrates of the mammalian target of rapamaycin complex 1 (mTORC1).

Identification and characterization of novel substrates of the mammalian target of rapamaycin complex 1 (mTORC1).
哺乳动物雷帕霉素复合物靶标 1 (mTORC1) 的新型底物的鉴定和表征。
批准号：
224753
负责人：
Topisirovic Ivan
金额：
$41.92万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-03-01 至 2016-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=224753&lang=en
关键词：
Cell Proliferation And Growth Mammalian Target Of Rapamycin Mass Spectrometry Metabolism Tumorigenesis

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英文摘要
The activity of the mammalian target of rapamycin complex 1 (mTORC1) is frequently dysregulated in human diseases characterized by abnormal metabolism and proliferation such as diabetes, cancer and heart disease. Accordingly, compounds modulating the acti
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