CCN proteins as emerging therapeutic targets for the treatment of degenerative disc disease

CCN 蛋白作为治疗退行性椎间盘疾病的新兴治疗靶点

• 批准号: 307814
• 负责人: Bedore Jacob M
• 金额: $ 7.65万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-10-01 至 2016-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307814&lang=en
• 关键词: Behavioral Pain Studies; Biomedical Imaging Modalities; Cellular Aging; Collagenopathy; Degenerative Disc Disease; Extracellular Microenvironment; Intervertebral Disc; Matricellular Proteins; Tissue Repair; Tissue-Specific Gene Kncokout Models

Back pain as a result of intervertebral disc (IVD) degeneration is a cause of major disability and constitutes the leading musculoskeletal disorder responsible for days lost from work. Studies show that chronic back pain is increasing at an alarming rate;

由于椎间盘（IVD）退变导致的背痛是导致严重残疾的原因，并构成导致工作日损失的主要肌肉骨骼疾病。研究表明，慢性背痛正以惊人的速度增加;