Human cathelicidin peptide LL-37 and its derivative IG-19 regulate IL-32-induced inflammation and provide protection in a murine model of arthritis

人导管素肽 LL-37 及其衍生物 IG-19 调节 IL-32 诱导的炎症并在小鼠关节炎模型中提供保护

• 批准号: 307741
• 负责人: Choi Ka-Yee Grace
• 金额: $ 7.65万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-10-01 至 2016-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307741&lang=en
• 关键词: Cathelicidin Ll37; Cytokine Il-32; Host Defense Peptide; Immune Regulation; Inflammation; Inflammatory Arthritis; Mouse Model Of Arthritis; Proteomics; Signal Transduction

Rheumatoid arthritis and related inflammatory arthritis diseases collectively affect 16% of Canadians with an estimated socio-economic burden of $6 billion annually. The symptoms associated with these debilitating diseases are the result of an underlying

风湿性关节炎和相关的炎症性关节炎疾病总共影响了16%的加拿大人，估计每年造成60亿美元的社会经济负担。与这些衰弱疾病相关的症状是一种潜在的