Effects of chronic D2/3 agonist ropinirole medication and a D4 antagonist on gambling behaviour in a 6-OHDA rodent model of Parkinson's disease

慢性 D2/3 激动剂罗匹尼罗药物和 D4 拮抗剂对帕金森病 6-OHDA 啮齿动物模型赌博行为的影响

• 批准号: 307770
• 负责人: Tremblay Melanie
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-10-01 至 2016-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307770&lang=en
• 关键词: Animal Model; Chemical Lesions; Decision-Making; Dopamine; Gambling; Parkinson'S Disease; Pharmacology; Striatum

This project aims to investigate the involvement of specific dopamine receptors on models of gambling behaviour, both in normal rats and in a rodent model of Parkinson's disease (PD). The more traditional drug treatment for PD, L-DOPA, has been shown over

该项目旨在研究特定的多巴胺受体在赌博行为模型中的作用，包括正常大鼠和帕金森氏病(PD)啮齿动物模型。治疗帕金森病的更传统的药物L-多巴已被展示