The effects of DNMT3B silencing on DNA methylation and tumorigenesis in a human embryonal tumor cell line

DNMT3B沉默对人胚胎肿瘤细胞系DNA甲基化和肿瘤发生的影响

• 批准号: 331470
• 负责人: Bajic Andrea
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-12-01 至 2015-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331470&lang=en
• 关键词: Dna Methylation; Dna Methyltransferase Gene Dnmt3b; Embryonal Tumor With Multilayered Rosettes (Etmr); Knockdown/Silencing Of Gene Expression; Pediatric Brain Tumors; Rna Interference; Tumorigenesis

Embryonal tumor with multilayered rosettes (ETMR) is a rare pediatric brain tumor, mostly affecting children under the age of four. ETMRs are highly malignant with survival of less than two years after diagnosis. Better understanding of these aggressive p

具有多层玫瑰花环的胚胎肿瘤(ETMR)是一种罕见的儿科脑肿瘤，多见于四岁以下儿童。ETMR是高度恶性的，确诊后存活不到两年。更好地理解这些积极的策略