Allosteric modulation of signaling through the parathyroid hormone 1 receptor by extracellular nucleotides

细胞外核苷酸对甲状旁腺激素 1 受体信号传导的变构调节

• 批准号: 323099
• 负责人: Chidiac Peter
• 金额: $ 23.68万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2018-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=323099&lang=en
• 关键词: Adenylyl Cyclase; Biased Agonism; Bone Metabolism; Drug Side Effects; Extracellular Nucleotides; Osteoporosis; Parathyroid Hormone Receptor; Positive Allosteric Modulator (Pam); Receptor Pharmacology; Signal Transduction

ATP (adenosine triphosphate) is a vitally important molecule that is best known for its ability to store and transfer energy in the cell, however it also plays many other biological roles. We have discovered that ATP on the outside of cells can greatly en

ATP（三磷酸腺苷）是一种非常重要的分子，以其在细胞中储存和转移能量的能力而闻名，但它也发挥着许多其他生物学作用。我们已经发现，细胞外的ATP可以极大地增强细胞的活力。