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Allosteric modulation of signaling through the parathyroid hormone 1 receptor by extracellular nucleotides

Allosteric modulation of signaling through the parathyroid hormone 1 receptor by extracellular nucleotides
细胞外核苷酸对甲状旁腺激素 1 受体信号传导的变构调节
批准号：
323099
负责人：
Chidiac Peter
金额：
$23.68万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-03-01 至 2018-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=323099&lang=en
关键词：
Adenylyl Cyclase Biased Agonism Bone Metabolism Drug Side Effects Extracellular Nucleotides Osteoporosis Parathyroid Hormone Receptor Positive Allosteric Modulator (Pam) Receptor Pharmacology Signal Transduction

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ATP (adenosine triphosphate) is a vitally important molecule that is best known for its ability to store and transfer energy in the cell, however it also plays many other biological roles. We have discovered that ATP on the outside of cells can greatly en
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Allosteric regulation of GPCR signaling by extracellular nucleotides
  • 批准号：
    390899
  • 项目类别：
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  • 资助金额：
    $53.22万
  • 财政年份：
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  • 依托单位：
    University of Western Ontario
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  • 财政年份：
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  • 负责人：
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