Investigation of the molecular mechanisms leading to polarized Sonic Hedgehog signal transduction in axonal growth cones

轴突生长锥极化 Sonic Hedgehog 信号转导的分子机制研究

• 批准号: 319229
• 负责人: Ferent Julien
• 金额: $ 9.83万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=319229&lang=en
• 关键词: Axon Guidance; Boc Receptor; Commissural Neurons; Growth Cone; Neural Development; Numb; Par Complex; Polarity; Sonic Hedgehog

Our brain and spinal cord is a very complex assembly of millions of cells that are linked to each other by specific connections. The way each neuron sends its principal projection, called the axon, to contact precisely other neurons is crucial. This netwo

我们的大脑和脊髓是由数百万个细胞组成的非常复杂的集合，这些细胞通过特定的连接相互联系。每个神经元发送其被称为轴突的主要投射以精确联系其他神经元的方式至关重要。这两个网络