Topoisomerase II beta occupancy and ablation in human cancer cells

人类癌细胞中拓扑异构酶 II β 的占据和消融

• 批准号: 364841
• 负责人: Su Qiao
• 金额: $ 0.36万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2017-05-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=364841&lang=en
• 关键词: Genomics; Top2b

Type II topoisomerases (TOP2) are enzymes that catalyze the formation and rejoining of double stranded breaks (DSB) in the genome. TOP2 poisons are used to treat many types of cancer by causing DNA damage to cancerous cells. However, these poisons interfe

II型拓扑异构酶（TOP 2）是催化基因组中双链断裂（DSB）的形成和重新连接的酶。TOP2毒物通过对癌细胞造成DNA损伤来治疗许多类型的癌症。然而，这些毒药干扰