How is p97 directed to its many functions? An NMR study of p97/p47 interactions

p97 是如何发挥其众多功能的？

• 批准号: 377065
• 负责人: Huang Rui
• 金额: $ 9.83万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-11-01 至 2020-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=377065&lang=en
• 关键词: Aaa Atpase; Disease Mutants; Isotope Labeling; Membrane Fusion; Neurodegenerative Disorders; P47; P97/Cdc48/Vcp; Protein Solution Nmr Spectroscopy; Structure And Dynamics; Supramolecular Machinary

Many molecular machines convert the energy from ATP hydrolysis into changes in the structures of the molecules that they act upon. As one of the most abundant machines in the cell, p97 is involved in a number of cellular functions including protein qualit

许多分子机器将ATP水解产生的能量转化为它们所作用的分子结构的变化。作为细胞中最丰富的机器之一，p97参与了许多细胞功能，包括蛋白质质量，