A New Entity of Cardiac Arrhythmia Associated with Loss of Cardiac Ryanodine Receptor Function

与心脏兰尼丁受体功能丧失相关的一种新的心律失常

• 批准号: 371476
• 负责人: Chen Sui Rong W
• 金额: $ 73.29万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371476&lang=en
• 关键词: Calcium Imaging; Cardiac Arrhythmias Sudden Death; Disease Mutations; Electrophysiology; Knock-In Mouse Models; Ryanodine Receptor Ca Release Channel; Single Channel Recordings; Sr Calcium Release; Structure And Function

In the heart, muscle contraction is triggered by the release of calcium from the internal calcium stores through the calcium release channel, called the ryanodine receptor type 2 (RyR2). It has been well established that enhanced RyR2 activity as a result

在心脏中，肌肉收缩是由内部钙库通过钙释放通道（称为 2 型兰尼碱受体 (RyR2)）释放钙来触发的。已证实 RyR2 活性增强