Molecular and biomechanical studies of bacterial-vascular adhesion mechanisms and their contributions to Lyme disease

细菌-血管粘附机制及其对莱姆病的贡献的分子和生物力学研究

• 批准号: 382396
• 负责人: Moriarty Tara J
• 金额: $ 57.12万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=382396&lang=en
• 关键词: Adhesion Complexes; Blood--Non-Cellular Components; Blood-Borne Infections; Catch Bonds; Endothelial Cells And Receptors; Endothelial Glycocalyx; Lyme Disease; Shear Stress; Spirochetes; Tissue Tropism

Blood-borne spread of bacteria via the cardiovascular system (dissemination) is responsible for most death due to bacterial infection. A key dissemination step is bacterial adhesion to the cells lining blood vessels (endothelial cells), which permits bact

细菌经心血管系统经血液传播（传播）是造成大多数细菌感染死亡的原因。一个关键的传播步骤是细菌粘附到血管内膜细胞（内皮细胞）上，这允许细菌传播