Determining The Molecular Mechanisms of Cell-Cell Fusion in Muscle Development and Regeneration

确定肌肉发育和再生中细胞与细胞融合的分子机制

• 批准号: 404188
• 负责人: Zhang Yichi
• 金额: $ 7.65万
• 依托单位: University of Texas Southwestern Medical Center
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=404188&lang=en
• 关键词: Cell Fusion; Crispr Loss-Of-Function Screening; Crispr-Cas9; Development; High Resolution Confocal Microscopy; Knockout Mice; Muscle Injury; Regeneration; Tandem Affinity Purification; Time-Lapse Imaging

The formation of skeletal muscle during development and following muscle injury requires muscle cells to fuse with each other and with existing muscle to form mature muscle fibers. Our laboratory has recently discovered two proteins localized to the cell

骨骼肌在发育过程中和肌肉损伤后的形成需要肌细胞彼此融合并与现有肌肉融合以形成成熟的肌纤维。我们的实验室最近发现了两种定位于细胞的蛋白质